Helicobacter pylori cell envelope and intracellular proteins

Helicobacter pylori cell envelope and intracellular proteins encompass the entire functional and structural proteome of the H. pylori bacterium, a Gram-negative pathogen that colonizes the human stomach. This collective target includes essential survival enzymes like urease, which allows the bacteria to survive in acidic environments, and virulence factors such as Cytotoxin-associated gene A (CagA) and Vacuolating cytotoxin A (VacA) that drive gastric inflammation and oncogenesis (StatPearls, 2023). These proteins are the primary targets for antibiotic therapy and are used as antigens in diagnostic assays and experimental vaccine development (NIH, 2022). Eradication of H. pylori through the targeting of these proteins is the standard of care for preventing peptic ulcers and reducing the risk of gastric cancer (WHO, 2021). The cell envelope proteins specifically facilitate adhesion to the gastric epithelium, while intracellular proteins manage DNA replication and protein synthesis. Pharmacological intervention typically involves a combination of antibiotics that disrupt these various bacterial components simultaneously. However, the increasing prevalence of antibiotic resistance against these targets poses a significant challenge to global health (PubMed, 2022).

Other names

Helicobacter pylori antigensH. pylori proteomeH. pylori whole-cell lysate

Inhibition of cell wall synthesis, inhibition of protein synthesis, DNA damage, and inhibition of urease activity.