Helicobacter pylori cell membrane and associated bacterial proteins (H. pylori cell membrane)

Helicobacter pylori is a Gram-negative bacterium that colonizes the human gastric mucosa, where it is a primary cause of chronic gastritis, peptic ulcers, and gastric adenocarcinoma (Kusters et al., 2006, Clinical Microbiology Reviews). The cell membrane and its associated proteins form a complex envelope essential for surviving the stomach's acidic environment and facilitating host colonization (Mobley et al., 1995, Microbiological Reviews). This structure includes an outer membrane rich in proteins like BabA and SabA, which mediate adhesion to gastric epithelial cells, and the urease enzyme complex, which neutralizes acid by producing ammonia (Ilver et al., 1998, Science). The cell envelope also contains lipopolysaccharides that can mimic host Lewis antigens to facilitate immune evasion (Appelmelk et al., 1996, Infection and Immunity). Many current treatments target this envelope; for instance, amoxicillin inhibits peptidoglycan synthesis within the cell wall, leading to bacterial lysis (StatPearls, 2023). As antibiotic resistance increases, the specific proteins and lipids of the H. pylori membrane continue to be investigated as targets for novel therapeutics and vaccine development.

Other names

H. pylori cell envelopeH. pylori outer membraneH. pylori plasma membraneH. pylori surface proteins

Inhibition of peptidoglycan biosynthesis, disruption of cell membrane integrity, and inhibition of membrane-associated enzymes and adhesins.