Helicobacter pylori energy metabolism and ATP-generating enzymes

Helicobacter pylori energy metabolism and ATP-generating enzymes are a group of essential proteins that facilitate the production of cellular energy in the microaerophilic environment of the human stomach (Source: PubMed 11544346). This group includes key enzymes such as pyruvate:ferredoxin oxidoreductase (PFOR), 2-oxoglutarate:ferredoxin oxidoreductase (OOR), and the F1F0-ATP synthase complex (Source: PubMed 10411741). These enzymes are vital for H. pylori to maintain its proton motive force and synthesize ATP, which are necessary for motility, acid resistance, and colonization. Because H. pylori employs metabolic pathways that differ significantly from those of the human host, these enzymes serve as selective targets for antimicrobial agents. For example, the drug nitazoxanide inhibits PFOR, while nitroimidazoles like metronidazole are activated by these metabolic enzymes into reactive radicals that damage bacterial DNA (Source: PubMed 16126513, 9603877). Inhibition of these energy-generating processes leads to the cessation of bacterial growth and eventual cell death. Consequently, these enzymes are central to the pharmacological management of H. pylori infections, which are linked to chronic gastritis, peptic ulcers, and gastric adenocarcinoma (Source: NIH).

Other names

H. pylori energy metabolism enzymesATP-generating enzymes of H. pyloriHelicobacter pylori respiratory enzymes

Inhibition of essential metabolic enzymes such as pyruvate:ferredoxin oxidoreductase (PFOR) or F1F0-ATP synthase, leading to the disruption of ATP production and cellular energy homeostasis (Source: PubMed 16126513, 15659676).