Helicobacter pylori ribosome (H. pylori ribosome)

The Helicobacter pylori ribosome is the central apparatus for protein synthesis in this Gram-negative pathogen, playing a vital role in its colonization and persistence within the acidic gastric environment (Source: PubMed, PMID: 30254144). It is composed of the 30S and 50S subunits, which together form the 70S complex that translates messenger RNA into polypeptides (Source: UniProt). This machinery is the primary therapeutic target for key antibiotics in standard eradication regimens, such as clarithromycin and tetracycline (Source: StatPearls, NBK544250). Clarithromycin acts by binding to the peptidyl transferase center of the 23S ribosomal RNA in the 50S subunit, effectively halting protein elongation (Source: NIH, PMC6502204). Tetracycline inhibits the 30S subunit by preventing the association of aminoacyl-tRNA with the ribosomal A-site (Source: PubMed, PMID: 28942494). Resistance to these drugs, often mediated by specific point mutations in the 23S or 16S rRNA genes, remains a significant challenge in treating H. pylori-related diseases like peptic ulcers and gastric adenocarcinoma (Source: NIH, PMC7074501).

Other names

Helicobacter pylori protein synthesis machinery70S ribosomeBacterial translation machinery

Inhibition of bacterial protein synthesis by binding to the 30S or 50S ribosomal subunits, thereby blocking the elongation phase of translation or preventing the binding of aminoacyl-tRNA.