Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Helicobacter pylori Urease Subunit B (UreB)
- Target
- UreB
- Molecular classification
- Enzyme subunit, Structural protein
01
Overview
Urease subunit B (UreB) is a structural component of the urease enzyme complex in Helicobacter pylori. UreB is essential for the enzymatic activity of urease, which hydrolyzes urea to produce ammonia and carbon dioxide, neutralizing gastric acid. It also binds directly to CD74 on gastric epithelial cells, triggering inflammation. Due to its immunogenicity and essential role, it is a vaccine target.
- Other names
- Urease subunit betaureB proteinrUreb
02
Mechanism of action
Inhibition of UreB function to disrupt urea hydrolysis and/or blocking UreB interaction with CD74 to reduce inflammation.
03
Biological functions
Urea hydrolysisAcid neutralizationImmune response inductionVirulenceInflammation
04
Disease associations
GastritisPeptic ulcerGastric cancerH. pylori infection
05
Safety considerations
Potential for off-target effects on host ureases (if any)Induction of autoimmune responses
Beyond the preview
Go deeper on Helicobacter pylori Urease Subunit B (UreB).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Helicobacter pylori Urease Subunit B (UreB).