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Target intelligence / Profile preview
Helper T Cell Type 1 (Th1)
- Target
- Th1
- Molecular classification
- T cell subset, CD4+ T cell
01
Overview
Helper T cell type 1 (Th1) cells are a specialized subset of CD4+ T helper cells that play a central role in the adaptive immune response, particularly in defending against intracellular pathogens. Th1 cells orchestrate cell-mediated immunity by activating macrophages, cytotoxic CD8+ T cells, and natural killer (NK) cells through the secretion of specific cytokines such as IFN-gamma, IL-2 and TNF-alpha. While crucial for pathogen clearance, dysregulation can lead to autoimmune diseases and tissue-damaging hypersensitivity reactions.
- Other names
- T helper 1 cellT helper type 1 cellTh1 lymphocyte
02
Biological functions
Cell-mediated immunityMacrophage activationCytotoxic lymphocyte activationImmune response to intracellular pathogensPromotion of IgG class switching
03
Disease associations
InfectionAutoimmune diseases (e.g., type I diabetes, rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, psoriasis)Delayed-type hypersensitivity reactions
04
Safety considerations
Potential for excessive inflammation and tissue damageRisk of autoimmunity
05
Biomarkers
IFN-gamma levelsT-bet expressionIL-12Rβ2 expressionCCR5 expressionCXCR3 expression
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