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Target intelligence / Profile preview
Hemagglutinin Antigen of Influenza A Virus Subtype H1N1 (HA (H1N1))
- Target
- HA (H1N1)
- Molecular classification
- Glycoprotein, Viral protein, Membrane protein
01
Overview
Hemagglutinin (HA) is a homotrimeric glycoprotein on the surface of the influenza A (H1N1) virus, essential for viral infectivity. It mediates host cell attachment via sialic acid receptors and facilitates viral entry through membrane fusion. HA is a major antigenic determinant and a key target for neutralizing antibodies and vaccine development. The protein is cleaved into HA1 (receptor binding) and HA2 (fusion) subunits. The amino acid sequence at the cleavage site impacts pathogenicity.
- Other names
- H1N1 HemagglutininHAInfluenza A H1N1 Hemagglutinin
02
Mechanism of action
Neutralization of viral entry by blocking receptor binding or inhibiting membrane fusion.
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune recognition
04
Disease associations
InfectionInfluenzaViral pathogenesis
05
Safety considerations
Antigenic driftAntigenic shiftDevelopment of resistance to neutralizing antibodies
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