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Target intelligence / Profile preview
Hemagglutinin Antigen of Influenza B Virus (Yamagata Lineage)
- Molecular classification
- Surface glycoprotein, Viral protein, Hemagglutinin
01
Overview
The hemagglutinin (HA) antigen of the influenza B virus Yamagata lineage is a surface glycoprotein essential for viral entry into host cells. It mediates binding to sialic acid receptors and facilitates membrane fusion. As a major antigenic determinant, it is a primary target for neutralizing antibodies and a key component of influenza vaccines. Antigenic differences between the Yamagata and Victoria lineages necessitate lineage-specific vaccine components. The Yamagata lineage has not been detected in circulation since March 2020 and its status is currently under review.
- Other names
- Influenza B Yamagata HemagglutininHA (Yamagata Lineage)B/Yamagata HA
02
Mechanism of action
Neutralization of viral entry by blocking receptor binding or membrane fusion.
03
Biological functions
Host cell receptor bindingMembrane fusionViral entryAntigen presentation
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Antigenic drift leading to vaccine mismatchPotential for antibody-dependent enhancement (ADE), though less common than in other viruses
06
Interacting drugs
Influenza vaccines
1 more in the full profile.
07
Biomarkers
Antibody titers against Yamagata HAHA sequence variations (for strain identification)
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