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Hemagglutinin Antigen of Influenza B Yamagata Lineage (HA (Yamagata))
- Target
- HA (Yamagata)
- Molecular classification
- Glycoprotein, Viral protein, Surface antigen
01
Overview
The hemagglutinin (HA) antigen is a major surface glycoprotein of the Influenza B virus, specifically from the Yamagata lineage. HA mediates binding to sialic acid-containing receptors on host cells, facilitating viral attachment and subsequent membrane fusion required for infection. It is a primary target for neutralizing antibodies and a key component of influenza vaccines. While historically a significant circulating lineage, naturally occurring cases of B/Yamagata have not been confirmed since March 2020, raising questions about its possible extinction.
- Other names
- Influenza B Yamagata HemagglutininB/Yamagata HAYamagata lineage hemagglutinin
02
Mechanism of action
Vaccines induce neutralizing antibodies that block HA-mediated viral entry. Therapeutic antibodies bind to HA and prevent viral attachment and fusion.
03
Biological functions
Viral entryReceptor bindingMembrane fusionImmune response induction
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Potential for antigenic drift leading to vaccine escapeRisk of vaccine-associated adverse events (generally low)
06
Interacting drugs
Influenza vaccines
1 more in the full profile.
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