Target intelligence / Profile preview

Hemagglutinin-Neuraminidase (HN)

Target: HN
Molecular classification: Viral Surface Glycoprotein, Enzyme, Glycoside Hydrolase family 83 (GH83)

Overview

Hemagglutinin-neuraminidase (HN) is a multifunctional viral surface glycoprotein found in several members of the Paramyxoviridae family. It mediates viral attachment to host cells, promotes membrane fusion, and exhibits neuraminidase activity, facilitating viral entry and release. HN is a target for antiviral drug development.

Mechanism of action

Inhibition of hemagglutinin-neuraminidase activity to prevent viral attachment, fusion, and release.

Biological functions

Viral attachmentPromotion of membrane fusionNeuraminidase activityReceptor bindingReceptor destructionViral entryViral release

Disease associations

MumpsParainfluenzaNewcastle disease (avian)

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