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Target intelligence / Profile preview
Hemagglutinin of Influenza A Virus H3N2 Subtype (HA (H3N2))
- Target
- HA (H3N2)
- Molecular classification
- Glycoprotein, Viral protein, Membrane protein
01
Overview
Hemagglutinin (HA) is a glycoprotein on the surface of the Influenza A virus H3N2 subtype. It mediates viral entry into host cells by binding to sialic acid receptors and facilitating membrane fusion. HA is a major target for neutralizing antibodies and vaccines due to its antigenicity.
- Other names
- H3N2 HemagglutininInfluenza A H3N2 HAHA trimer (H3N2)
02
Mechanism of action
Vaccines induce neutralizing antibodies that block HA binding or fusion. Antibodies may target the receptor binding site (RBS) or stem region, preventing viral entry into host cells.
03
Biological functions
Viral attachmentMembrane fusionReceptor binding (sialic acid)Immune recognitionAgglutination
04
Disease associations
InfectionInfluenzaSeasonal fluPandemic (e.g., Hong Kong Flu)
05
Safety considerations
Antigenic drift (reduced vaccine effectiveness)Antigenic shift (pandemic potential)Strain-specific immunityRisk of vaccine mismatch
06
Interacting drugs
Neutralizing antibodies
2 more in the full profile.
07
Biomarkers
HA antibody titers (vaccine efficacy)HA mutations (antigenic drift)HA sequence (viral strain identification)
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