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Target intelligence / Profile preview
Hemagglutinin of influenza A virus H9 subtype (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Class I fusion protein
01
Overview
Hemagglutinin of influenza A virus H9 subtype (HA) is a homotrimeric glycoprotein on the viral envelope, consisting of HA1 (head with receptor binding domain) and HA2 (stalk with fusion peptide) subunits. It mediates viral attachment to sialic acid receptors on host cells (e.g., α2,6-linked in mammals) and low-pH-induced fusion of viral and endosomal membranes for entry. H9 HA shows structural differences from H3/H5 subtypes, lacking a lateral loop equivalent to antigenic site A, with unique antigenic sites influencing antibody escape, virulence, and receptor affinity. It is a key target for antivirals and vaccines due to its role in infection.
- Other names
- H9 hemagglutininH9 HA
02
Mechanism of action
Inhibits viral binding to sialic acid receptors, Blocks virus-host membrane fusion by targeting HA stem or head domains, Neutralizes virus via antibody binding to receptor binding domain
03
Biological functions
Viral attachment to sialic acid receptorsVirus-host membrane fusionViral entry into host cells
04
Disease associations
Infection
05
Safety considerations
Antigenic variation and escape mutations reduce antibody efficacyPotential for decreased virulence or altered receptor affinity in mutants
06
Interacting drugs
CL-385319 (binds HA2 stem region)
1 more in the full profile.
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