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Target intelligence / Profile preview
Hemagglutinin of Influenza B Victoria-lineage virus (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral protein, Surface antigen
01
Overview
The hemagglutinin (HA) protein is a major surface glycoprotein of the Influenza B virus (Victoria lineage). It mediates viral entry into host cells by binding to sialic acid-containing receptors and is the primary target of neutralizing antibodies. Antigenic drift in HA necessitates continuous vaccine updates to match circulating strains. HA is a homotrimer, consisting of HA1 (receptor binding) and HA2 (fusion) subunits. The Victoria lineage is antigenically distinct from the Yamagata lineage.
- Other names
- Influenza B HemagglutininHA proteinB/Victoria lineage HA
02
Mechanism of action
Mediates viral entry into host cells by binding to sialic acid-containing receptors on the cell surface. Target of neutralizing antibodies, preventing viral attachment and entry.
03
Biological functions
Viral entryCell attachmentMembrane fusionAntigen presentationImmune evasion
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Antigenic drift leading to vaccine mismatchPotential for increased disease severity due to lineage-specific immune responses
06
Interacting drugs
NA inhibitors (e.g., Oseltamivir, Zanamivir) - indirect effect by preventing viral release
07
Biomarkers
Antibody titers against HAHA sequence variants
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