Target intelligence / Profile preview

Hemagglutinin protein (influenza H3) (HA)

Target: HA
Molecular classification: Glycoprotein, Viral protein, Membrane protein

Overview

Hemagglutinin (HA) is a trimeric glycoprotein found on the surface of influenza A viruses, specifically the H3 subtype. It mediates both attachment to host cells and fusion of viral and cellular membranes, making it essential for viral infectivity. The HA protein is the primary target for neutralizing antibodies generated by infection or vaccination. Antigenic drift within the HA sequence necessitates continuous vaccine updates.

Mechanism of action

N/A

Biological functions

Receptor bindingMembrane fusionAntigen presentation

Disease associations

InfectionInfluenza

Safety considerations

Antigenic drift leading to vaccine escapePotential for antibody-dependent enhancement (ADE)

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