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Hemagglutinin Protein of Influenza A Virus (Stalk Domain) (HA Stalk)
- Target
- HA Stalk
- Molecular classification
- Viral Protein, Membrane Fusion Protein, Type I transmembrane glycoprotein
01
Overview
The hemagglutinin (HA) stalk domain is a conserved region of the influenza A virus hemagglutinin protein. It is located at the membrane-proximal region of the protein and plays a crucial role in mediating pH-dependent fusion between viral and endosomal membranes, facilitating viral entry into host cells. Due to its relatively high conservation across different influenza strains, it represents an attractive target for the development of broadly protective vaccines and antiviral therapies.
- Other names
- HA2Hemagglutinin StalkInfluenza Hemagglutinin Stalk Domain
02
Mechanism of action
Inhibition of membrane fusion, neutralization, ADCC, ADCP, Complement activation
03
Biological functions
Membrane fusionViral entrypH-triggered conformational change
04
Disease associations
InfectionInfluenzaViral disease
05
Safety considerations
Potential for off-target effects of immunotherapiesEliciting unwanted immune responses
06
Interacting drugs
Broadly neutralizing antibodies (bnAbs)
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