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Hemagglutinin Protein of Influenza A Virus H3N2 Subtype (HA (H3N2))
- Target
- HA (H3N2)
- Molecular classification
- Viral Surface Glycoprotein, Class I Viral Fusion Protein
01
Overview
Hemagglutinin (HA) is a major surface glycoprotein of the influenza A virus, including the H3N2 subtype. It mediates attachment to host cell receptors and facilitates membrane fusion, essential for viral entry and infectivity. HA is a homotrimer comprised of HA1 and HA2 subunits. Due to its immunodominance and variability, hemagglutinin sequence changes drive annual updates to influenza vaccines. The H3N2 subtype emerged during the Hong Kong flu pandemic (1968–1969) from reassortment events.
- Other names
- H3N2 HemagglutininHA protein (H3N2)Influenza A H3N2 HA
02
Mechanism of action
Viral attachment to sialic acid receptors on host cells, followed by conformational change and membrane fusion upon endocytosis and exposure to acidic pH.
03
Biological functions
Viral attachment to host cellsMembrane fusionReceptor bindingAntigen presentation
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Antigenic drift leading to vaccine escapePotential for reassortment with other influenza virusesImmunogenicity (potential for adverse reactions to vaccines)
06
Interacting drugs
NA inhibitors (e.g., Oseltamivir, Zanamivir) - indirectly reduce HA-mediated infection
2 more in the full profile.
07
Biomarkers
HA antibody titers (for vaccine efficacy)HA sequence variants (for monitoring antigenic drift)HA expression levels (in infected cells)
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