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Target intelligence / Profile preview
Hemagglutinin Protein of Influenza A Virus Subtype H1N1 (HA)
- Target
- HA
- Molecular classification
- Viral Protein, Glycoprotein, Surface Antigen
01
Overview
Hemagglutinin (HA) is a major surface glycoprotein of the Influenza A virus, including the H1N1 subtype. It mediates attachment to host cells and membrane fusion, enabling viral entry. HA is the primary target for neutralizing antibodies and thus central to immune recognition and vaccine design. Each HA monomer is cleaved into HA1 (receptor binding) and HA2 (membrane fusion). Variations influence species specificity (host range) and virulence. Because it mediates attachment and entry steps, and elicits strong antibody responses, HA is a prime target for vaccines, therapeutic antibodies, and antiviral drug development.
- Other names
- H1N1 HemagglutininHA proteinH1 hemagglutinin
02
Mechanism of action
Blocks receptor binding or prevents membrane fusion
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune response elicitation
04
Disease associations
InfectionInfluenzaPandemicViral pathogenesis
05
Safety considerations
Antigenic driftAntigenic shiftResistance to antiviral drugsPotential for vaccine escape
06
Interacting drugs
Therapeutic antibodies
1 more in the full profile.
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