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Target intelligence / Profile preview
Hemagglutinin Protein of Influenza A Virus Subtype H7N9 (HA)
- Target
- HA
- Molecular classification
- Glycoprotein, Viral surface protein, Fusion protein
01
Overview
Hemagglutinin (HA) is a surface glycoprotein found on the envelope of Influenza A virus subtype H7N9. It is responsible for binding to sialic acid receptors on host cells and mediating fusion between the viral envelope and host endosomal membrane, enabling viral entry. HA's receptor specificity and mutations significantly impact host range, virulence, and immune evasion, making it a critical target for antiviral drug and vaccine development.
- Other names
- H7N9 HemagglutininHA proteinInfluenza A H7N9 HA
02
Mechanism of action
Drugs targeting HA typically inhibit receptor binding or membrane fusion, preventing viral entry into host cells.
03
Biological functions
Viral attachmentReceptor bindingMembrane fusionViral entryImmune evasion
04
Disease associations
InfectionInfluenzaZoonotic diseaseRespiratory disease
05
Safety considerations
Antigenic drift and shift leading to vaccine escapePotential for increased virulence and transmissibility with mutations
06
Biomarkers
HA antibody titers (for vaccine efficacy)HA mutations (for drug resistance)
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