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Hemagglutinin protein of Influenza B Victoria lineage
- Molecular classification
- Surface glycoprotein, Viral protein, Hemagglutinin, Class I viral fusion protein
01
Overview
The hemagglutinin (HA) protein of the Influenza B Victoria lineage is a homotrimeric glycoprotein on the viral surface crucial for host cell attachment and membrane fusion during viral entry. It binds to sialic acid receptors and is a major target for neutralizing antibodies, making it a key component of influenza vaccines. The Victoria lineage HA exhibits high antigenic diversity due to insertions/deletions in its receptor binding site, leading to immune evasion.
- Other names
- HA protein of Influenza B Victoria lineageInfluenza B Victoria lineage hemagglutinin
02
Mechanism of action
Vaccines elicit neutralizing antibodies that block HA-mediated attachment and fusion. NA inhibitors prevent viral release.
03
Biological functions
Host cell attachmentSialic acid bindingMembrane fusionViral entryAntigen presentationImmune response elicitation
04
Disease associations
InfectionInfluenzaRespiratory disease
05
Safety considerations
Antigenic drift leading to vaccine mismatchPotential for vaccine-associated adverse events (rare)
06
Interacting drugs
Influenza vaccines
1 more in the full profile.
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