Hemagglutinin Protein of Influenza B Victoria Lineage Virus (HA)

The hemagglutinin (HA) protein is a major surface glycoprotein of the Influenza B virus, specifically within the Victoria lineage. It mediates viral entry by binding to host cell receptors and facilitating membrane fusion. HA is the primary target for neutralizing antibodies, making it crucial for immune recognition and vaccine design. The Victoria lineage exhibits significant antigenic diversity due to frequent mutations in the HA receptor binding site, enabling immune evasion. Recombinant forms of Victoria-lineage HA are utilized in diagnostic assays and influenza vaccines.

Other names

B/Victoria lineage HAInfluenza B HemagglutininHA protein

Vaccines elicit neutralizing antibodies that bind to HA, preventing viral attachment and entry. Antibodies also promote antibody-dependent cell-mediated cytotoxicity (ADCC).