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Target intelligence / Profile preview
Hemagglutinin protein of Influenza B virus Victoria lineage (HA)
- Target
- HA
- Molecular classification
- Viral protein, Glycoprotein
01
Overview
The hemagglutinin (HA) protein is a major surface glycoprotein of Influenza B viruses, specifically those belonging to the Victoria lineage. It mediates viral attachment to host cells and subsequent membrane fusion, enabling viral entry. HA is a key antigenic determinant and the primary target for neutralizing antibodies. Due to antigenic differences between Victoria and Yamagata lineages, vaccines must include components from both to provide broad protection.
02
Mechanism of action
Antibody neutralization of HA, inhibition of viral entry
03
Biological functions
Viral entryReceptor bindingMembrane fusionImmune recognition
04
Disease associations
InfectionInfluenza
05
Safety considerations
Antigenic driftLack of cross-protection between Victoria and Yamagata lineages
06
Interacting drugs
NA inhibitors
1 more in the full profile.
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