Hemagglutinin protein of Influenza B virus Yamagata lineage (HA (Yamagata lineage))

The hemagglutinin (HA) protein of the Influenza B virus Yamagata lineage is a major surface glycoprotein essential for viral entry into host cells. It mediates attachment to sialic acid receptors and subsequent membrane fusion. As a key immunogen, it is a crucial component of influenza vaccines, particularly quadrivalent formulations targeting both Yamagata and Victoria lineages. Antigenic variations within HA necessitate continuous surveillance and vaccine updates.

Other names

Influenza B Hemagglutinin (Yamagata)B/Yamagata HAHA protein (Yamagata lineage)

Binding to sialic acid receptors on host cells, triggering receptor-mediated endocytosis, followed by pH-dependent conformational change and membrane fusion. Vaccines elicit neutralizing antibodies that block HA's function.