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Target intelligence / Profile preview
Hemagglutinin Stalk Domain (Group 1 Influenza A) (HA Stalk)
- Target
- HA Stalk
- Molecular classification
- Viral Protein, Membrane Fusion Protein, Glycoprotein
01
Overview
The hemagglutinin (HA) stalk domain is a highly conserved region of the influenza A virus HA protein, particularly within phylogenetic group 1 subtypes. It is located proximal to the viral membrane and is structurally distinct from the immunodominant globular head domain. The HA stalk plays an essential role in membrane fusion during viral entry and is a target for broadly neutralizing antibodies.
- Other names
- HA Stem RegionHemagglutinin StemHA2 subunitInfluenza A Hemagglutinin StalkHA Group 1 Stalk
02
Mechanism of action
Antibodies targeting the HA stalk can neutralize diverse strains within group 1 by inhibiting membrane fusion or interfering with other steps required for infection. Some antibodies may also act via ADCC/ADCP or CDC.
03
Biological functions
Membrane FusionViral EntryAntigen presentationEliciting neutralizing antibodies
04
Disease associations
InfectionInfluenza A pathogenesis
05
Safety considerations
Potential for off-target effects of broadly neutralizing antibodiesRisk of escape mutations
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