Hematopoietic stem and progenitor cell compartment (HSPC compartment)

The hematopoietic progenitor/stem cell compartment is a collection of multipotent and self-renewing cells within the bone marrow and, during development, extramedullary tissues. Hematopoietic stem cells (HSCs) within this compartment possess the ability to differentiate into all mature blood cell lineages and sustain lifelong blood production. Hematopoietic progenitor cells (HPCs) are downstream, committed to specific lineages and lack extensive self-renewal. This compartment is defined and studied by cell-surface markers (such as CD34, CD133, Sca-1, c-Kit, and absence of mature lineage markers), and is essential for hematopoietic homeostasis, transplantation, and therapy for hematologic diseases. The "Hematopoietic progenitor/stem cell compartment" is not a molecular target or receptor but a functionally defined group of cells. Its use as a therapeutic or biomarker target is indirect, with clinical interventions focusing on the entire cellular compartment rather than a discrete molecular entity.

Other names

Hematopoietic progenitor and stem cell compartmentHematopoietic stem cell compartmentHSC/HPC compartmentHSPC compartment

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