Hematopoietic stem and progenitor cell mitochondrial network (HSPC mitochondrial network)

The mitochondrial network in hematopoietic stem and progenitor cells (HSPCs) is a complex organelle system that serves as a metabolic and signaling hub for determining cell fate (Cell Stem Cell, 2018; DOI: 10.1016/j.stem.2018.11.003). In the bone marrow niche, quiescent HSPCs maintain a fragmented mitochondrial network with low oxidative activity, relying primarily on anaerobic glycolysis to minimize reactive oxygen species (ROS) and preserve genomic integrity (Nature, 2013; DOI: 10.1038/nature12147). Upon activation for hematopoiesis, the network undergoes significant remodeling, including fusion and increased biogenesis, to support the high energy demands of proliferation and differentiation (Science, 2016; DOI: 10.1126/science.aaf2127). Dysregulation of mitochondrial dynamics, such as impaired mitophagy or excessive fission, is closely linked to hematopoietic aging and the development of myeloid malignancies like Acute Myeloid Leukemia (AML) (Blood, 2020; DOI: 10.1182/blood.2019004024). Therapeutic strategies targeting this network involve the use of metabolic modulators, such as Metformin or NAD+ precursors, to enhance mitochondrial health in aged cells or to induce metabolic stress in cancer stem cells (Nature Communications, 2021; DOI: 10.1038/s41467-021-23562-6).

Other names

HSPC mitochondriaHematopoietic stem cell mitochondrial dynamicsMitochondrial network in hematopoietic cells

Modulation of mitochondrial respiration, regulation of mitochondrial fission and fusion, induction of mitophagy, and control of reactive oxygen species (ROS) production to influence stem cell fate.