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Hematopoietic Stem and Progenitor Cells (HSPCs)
- Target
- HSPCs
- Molecular classification
- Stem Cells, Progenitor Cells
01
Overview
Hematopoietic stem and progenitor cells (HSPCs) are a rare, vital population of precursor cells responsible for the lifelong production and maintenance of all blood and immune cell types. They possess two defining properties: self-renewal (the ability to generate identical daughter cells) and multilineage differentiation (the capacity to give rise to all mature blood cell lineages).
- Other names
- Hematopoietic Stem CellsHSCsProgenitor CellsLT-HSCsLong-term HSCsST-HSCsShort-term HSCsMultipotent ProgenitorsCommon Myeloid ProgenitorsCommon Lymphoid Progenitors
02
Mechanism of action
Mobilization of HSPCs from bone marrow
03
Biological functions
HematopoiesisSelf-renewalMultilineage differentiationTissue regenerationImmune response
04
Disease associations
LeukemiaLymphomaHematologic malignanciesHematologic disorders
05
Safety considerations
Transplantation rejectionGraft-versus-host diseaseMobilization side effects
06
Interacting drugs
G-CSF
07
Biomarkers
CD34CD38CD201SLAM family markersMDR1/ABCG2c-Kit/CD117Sca1
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