Hematopoietic system (recipient)

The recipient hematopoietic system refers to all blood-forming tissues and cells—including hematopoietic stem and progenitor cells, mature blood lineages, and supportive bone marrow stroma—of an individual receiving a hematopoietic stem cell transplant. Clinical interventions such as HSCT ablate or replace this system to treat hematologic malignancies, bone marrow failures, and genetic disorders. The recipient system is not a drug target but a physiological entity that is reconstituted or replaced via transplantation, often involving significant safety and therapeutic challenges such as immunosuppression, risk of infection, and transplant complications like GVHD.

Other names

Hematopoietic systemHaematopoietic systemBlood-forming system

Chemotherapy/radiation: eradication/ablation of recipient’s hematopoietic (and immune) cells to enable engraftment of donor cells; Immunosuppression: prevention of graft rejection; Gene therapy: correction of genetic defects in hematopoietic stem cells.