Target intelligence / Profile preview

Heme

Molecular classification
Prosthetic Group, Cofactor, Porphyrin Complex
01

Overview

Heme is a small, ring-shaped iron-containing molecule that serves as an essential prosthetic group in various proteins, most notably hemoglobin. It is critical for oxygen transport in the bloodstream and plays diverse roles in redox reactions, electron transfer, and catalysis within living organisms. It consists of a central iron ion (Fe) coordinated to a porphyrin ring. Key biological roles include oxygen transport/storage, electron transfer, and enzymatic catalysis. Disorders involving abnormal synthesis or degradation include various types of anemia and porphyria syndromes.

Other names
HaemFerroprotoporphyrin IXFerrous protoporphyrin IX
02

Biological functions

Oxygen transportOxygen storageElectron transferEnzymatic catalysisRedox reactions
03

Disease associations

Anemia (related to synthesis defects)Porphyria (related to synthesis defects)

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