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Heme Biosynthesis Pathway
- Molecular classification
- Metabolic pathway
01
Overview
The heme biosynthesis pathway is a highly conserved metabolic process responsible for the production of heme, an essential prosthetic group found in hemoglobin, myoglobin, cytochromes, and other hemoproteins. Defects in this pathway can result in porphyrias or sideroblastic anemias.
02
Mechanism of action
Inhibition of enzymes in the heme biosynthesis pathway can be a mechanism of action for drugs treating porphyrias. Specific drugs would target specific enzymes within the pathway.
03
Biological functions
Heme synthesisOxygen transport cofactor productionElectron transfer cofactor productionCellular respiration
04
Disease associations
PorphyriasSideroblastic anemiasNeurovisceral disordersPhotosensitivity
05
Safety considerations
Drug-induced porphyria exacerbationPhotosensitivityNeurotoxicity due to accumulation of pathway intermediates
06
Biomarkers
Accumulation of heme precursors (e.g., porphyrins) in blood, urine, or feces
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