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Heme Detoxification Pathway

Molecular classification: Metabolic pathway

Overview

The heme detoxification pathway is a crucial metabolic process in the malaria parasite *Plasmodium falciparum*, converting toxic free heme released during hemoglobin digestion into inert hemozoin crystals. This pathway is essential for parasite survival and represents a validated target for antimalarial drug development.

Other names: Hemozoin formationMalaria pigment formation

Mechanism of action

Inhibition of hemozoin formation, leading to accumulation of toxic free heme

Biological functions

Heme detoxificationProtection against oxidative stressParasite survival

Disease associations

InfectionMalaria

Safety considerations

Development of drug resistance

Interacting drugs

Chloroquine

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