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Heme Detoxification Protein (HDP)

Target: HDP
Molecular classification: Enzyme

Overview

Heme Detoxification Protein (HDP) is a key enzyme involved in the heme detoxification pathway in *Plasmodium falciparum*. It catalyzes or facilitates the conversion of toxic free heme into inert hemozoin crystals within the parasite's food vacuole. HDP is essential for parasite survival and represents a major drug target for antimalarial therapy.

Other names: PF14_0446Hemozoin synthaseHeme ligase

Mechanism of action

Inhibition of hemozoin biocrystallization, leading to toxic buildup of unpolymerized (free) heme inside the food vacuole.

Biological functions

Heme detoxificationHemozoin formation

Disease associations

Infection

Interacting drugs

Chloroquine

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