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Target intelligence / Profile preview
Heme Oxygenase (HO)
- Target
- HO
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Heme oxygenase (HO) is an essential enzyme responsible for the oxidative degradation of heme, a process that produces biliverdin, ferrous iron (Fe²⁺), and carbon monoxide (CO). This reaction is crucial for heme catabolism and iron recycling in the body. The enzyme exists in multiple isoforms with distinct regulatory properties and tissue distributions, including HO-1 (inducible, stress-responsive), HO-2 (constitutive, involved in gas sensing), and HO-3 (less characterized, possibly a splice variant of HO-2).
02
Mechanism of action
Catalyzes the oxidative degradation of heme into biliverdin, ferrous iron, and carbon monoxide.
03
Biological functions
Heme catabolismIron recyclingAntioxidant defenseRegulation of inflammationGas sensing
04
Disease associations
Cardiovascular diseaseInflammatory disordersNeurodegenerative diseasesOxidative stress related diseases
05
Safety considerations
Potential toxicity from overproduction of CO or bilirubin
06
Biomarkers
HO-1 as a marker of oxidative stress
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