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Target intelligence / Profile preview
Heme Oxygenase 1 Induction (HO-1 Induction)
- Target
- HO-1 Induction
- Molecular classification
- Enzyme Induction, Transcription factor regulation
01
Overview
Heme Oxygenase-1 (HO-1) induction is a critical adaptive cellular response characterized by increased expression of the HMOX1 gene, leading to elevated levels of HO-1 protein. This enzymatic process degrades heme into biliverdin, free iron, and carbon monoxide, exerting antioxidant, anti-inflammatory, cytoprotective, and immunomodulatory effects. The process is primarily regulated by transcription factors like Nrf2 and Bach1, and can be triggered by various stressors including oxidative stress and inflammation. HO-1 induction has demonstrated therapeutic potential in diverse disease models but excessive or inappropriate induction may impair host defense.
- Other names
- HMOX1 inductionHO1 induction
02
Mechanism of action
Nrf2 activation, Bach1 inhibition, leading to increased HMOX1 gene transcription and subsequent HO-1 protein expression and activity.
03
Biological functions
AntioxidantAnti-inflammatoryCytoprotectionImmunomodulationRegulation of gene expression
04
Disease associations
InflammationOxidative StressCardiovascular diseaseNeurodegenerative diseaseIschemia-Reperfusion InjuryCancer
05
Safety considerations
Potential immunosuppressionContext-dependent effects
06
Interacting drugs
Curcumin
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