Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heme Oxygenase 2 (HO-2)
- Target
- HO-2
- Molecular classification
- Enzyme, Oxidoreductase
01
Overview
Heme oxygenase 2 (HO-2) is an enzyme that catalyzes the oxidative cleavage of heme, a process essential for heme catabolism and cellular homeostasis. HO-2 is a constitutive isoform, generally expressed at steady levels. It is highly abundant in the brain, testis, and endothelial cells, suggesting roles in neuroprotection and gas sensing. It differs from the inducible isoform HO-1. Unique structural elements such as heme regulatory motifs (HRMs) confer additional layers of regulation potentially related to redox status or gas sensing.
- Other names
- HMOX2
02
Mechanism of action
Catalyzes the degradation of heme into biliverdin, carbon monoxide, and ferrous iron.
03
Biological functions
Heme catabolismCarbon monoxide productionRedox regulationGas sensingNeuroprotection
04
Disease associations
Neurodegenerative diseaseOxidative stress-related diseasesOther (potential involvement in disease-modifying therapies)
Beyond the preview
Go deeper on Heme Oxygenase 2 (HO-2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heme Oxygenase 2 (HO-2).