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Heme polymerase

Molecular classification: Enzyme

Overview

Heme polymerase is an enzyme found in malaria parasites that catalyzes the conversion of ferriprotoporphyrin IX into hemozoin. This process is essential for the parasite's survival as it detoxifies free heme released during hemoglobin degradation. Inhibition of heme polymerase is the mechanism of action of several antimalarial drugs, such as chloroquine.

Other names: Ferriprotoporphyrin IX polymerization catalystHemozoin synthase

Mechanism of action

Inhibition of heme polymerization, leading to accumulation of toxic free heme within the parasite.

Biological functions

Detoxification of free hemeHemozoin biosynthesis

Disease associations

InfectionMalaria pathogenesis

Interacting drugs

Chloroquine

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