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Heme Polymerization

Molecular classification: Enzymatic process

Overview

Heme polymerization is a crucial detoxification pathway in malaria parasites (Plasmodium spp.) where toxic free heme, released during hemoglobin digestion, is converted into an inert crystalline pigment called hemozoin. This process is essential for parasite survival as free heme is highly toxic. Inhibition of heme polymerization is a validated antimalarial drug target.

Other names: Hemozoin formationβ-hematin formationMalaria pigment formation

Mechanism of action

Inhibition of heme polymerization leading to accumulation of toxic free heme.

Biological functions

Heme detoxificationParasite survival

Disease associations

Infection (Malaria)

Safety considerations

Drug resistance

Interacting drugs

Chloroquine

3 more in the full profile.

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