Hemidesmosome protein

Hemidesmosome proteins are not a single target or molecule but refer collectively to a group of multiprotein complexes critical for cell-extracellular matrix adhesion, especially in epithelial tissues[1][2][3][5][6]. Their key components include integrin α6β4, plectin, BP180 (collagen XVII), BP230, and the tetraspanin CD151, which together form anchor points linking the basal keratin cytoskeleton to the basement membrane[1][2][3][5][6]. These proteins are essential for tissue resilience, mechanical stability, and integrity of epithelial layers, and disruptions can lead to severe blistering diseases and contribute to tumor progression and invasion[3][4][5][6]. The entry as "Hemidesmosomal and Extracellular Matrix Proteins" is overly broad and refers to a functional class rather than a specific target; thus, it is not suitable as a canonical drug target. Note: - The provided name is not a specific molecule or receptor, but a descriptive phrase for a class of structural and matrix proteins. There is no single target with this name. - Proper categorization would require specifying individual proteins, such as "Integrin α6β4" or "Plectin."[1][3][6]

Other names

Hemidesmosomal proteinExtracellular matrix proteinHD protein