HemK methyltransferase family member 1 (HEMK1)

HemK methyltransferase family member 1 (HEMK1) is an evolutionarily conserved protein methyltransferase that catalyzes the N(5)-glutamine methylation of the universally conserved GGQ motif in mitochondrial translation release factors, specifically MTRF1, MTRF1L, MRPL58 (a.k.a. ICT1), and MTRFR[1][3][5]. This methylation event is important for maintaining translational fidelity and efficient translation termination in mitochondria[1][3]. HEMK1 is a S-adenosyl–L–methionine (SAM)–dependent enzyme with a dual-domain architecture, localized to the mitochondrion, and shares structural similarity with bacterial PrmC[1][3]. HEMK1 also appears to have roles in cell proliferation and immunomodulation in mammals, and bacterial homologs relate to virulence pathways, implicating the enzyme in broader cellular, developmental, and pathogenic processes[1][3][5]. Current research suggests disruption of HEMK1 does not have a substantial effect on general cellular growth or mitochondrial function in standard culture, but its full physiological and pathological significance is under continued investigation[3].

Other names

MTQ1HEMKHemKMTRF1L release factor glutamine methyltransferaseM.HsaHemKPMPRMCHEMK homolog 7kbm.HsaHemKPtestis secretory sperm-binding protein Li 225n