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Hemoglobin subunit alpha (HBA)

Target: HBA
Molecular classification: Globin family, Protein

Overview

Hemoglobin subunit alpha, encoded primarily by the HBA1 gene (and also by the HBA2 gene), is a critical component of hemoglobin, the oxygen-carrying protein in red blood cells. It forms tetramers with beta chains (HbA), delta chains (HbA2), or gamma chains (fetal HbF) and its primary function is oxygen transport. Mutations or deletions affecting the HBA1 or HBA2 genes lead to disorders such as alpha thalassemia.

Other names: Alpha-globinHemoglobin alpha chain

Biological functions

Oxygen transportIron ion bindingAllosteric regulation

Disease associations

Alpha thalassemiaAnemiaOxidative stress-induced inflammation

Safety considerations

Mutations can lead to alpha thalassemia, ranging from mild anemia to severe disease.

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