Hemoglobin subunit alpha 1 mRNA (HBA1 mRNA)

Hemoglobin subunit alpha 1 (HBA1) mRNA is the messenger RNA transcript that encodes the alpha-globin protein, a critical component of the adult hemoglobin (HbA) heterotetramer [1]. In humans, the alpha-globin chains are produced by two nearly identical genes, HBA1 and HBA2, which pair with beta-globin chains to form functional hemoglobin responsible for oxygen transport in red blood cells [2]. Deficiencies in the production or stability of HBA1 mRNA, often caused by genetic deletions or mutations, lead to alpha-thalassemia, a condition characterized by microcytic anemia and the formation of unstable hemoglobin variants like Hemoglobin H [3][4]. As a therapeutic target, HBA1 mRNA is the focus of emerging RNA-based strategies, including mRNA replacement therapies designed to restore functional alpha-globin levels in deficient patients [5]. Additionally, the regulatory elements within the HBA1 mRNA, such as the 3' untranslated region (UTR) which governs transcript stability, are subjects of research for modulating globin expression in various hemoglobinopathies [6].

Other names

Alpha-1 globin mRNAHBA1 transcriptHba-a1 mRNAAlpha-globin mRNA

mRNA replacement therapy and gene addition to restore functional alpha-globin protein levels.