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Target intelligence / Profile preview
Hemolysin alpha toxin (Hla)
- Target
- Hla
- Molecular classification
- Pore-forming toxin, Cytotoxin, β-barrel protein
01
Overview
Hemolysin alpha toxin (Hla) is a major cytotoxic protein secreted by *Staphylococcus aureus*. It is a pore-forming toxin that oligomerizes on host cell membranes to form a heptameric pore, leading to cell death via apoptosis or necrosis. Hla interacts with host cell receptors like ADAM10 and is a key virulence factor in *S. aureus* infections.
- Other names
- Alpha-toxinAlpha hemolysinStaphylococcus aureus alpha-toxinHly
02
Mechanism of action
Formation of heptameric pores in host cell membranes, leading to ion imbalance and cell death.
03
Biological functions
Cell lysisApoptosis inductionNecrosis inductionDisruption of ion homeostasisImmune cell impairmentPore formation
04
Disease associations
Pneumonia (Staphylococcus aureus)Skin infections (Staphylococcus aureus)Bacterial virulenceTissue damage during infection
05
Safety considerations
CytotoxicityPotential for off-target effects due to pore-forming activity
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