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Target intelligence / Profile preview
Heme Polymerase (Plasmodium falciparum) (HP)
- Target
- HP
- Molecular classification
- Enzyme (functional), Lipids (contributing), Protein complex
01
Overview
Heme polymerase in *Plasmodium falciparum* refers to the molecular machinery responsible for converting toxic free heme, released during hemoglobin digestion, into an inert crystalline pigment called hemozoin. This process is essential for parasite survival within red blood cells and is a validated target for antimalarial drug development. While Histidine-rich protein II (HRPII) is implicated as a key mediator, the exact molecular identity of the polymerase remains under investigation. Lipids may also contribute to the process.
- Other names
- Hemozoin formation machineryFerriprotoporphyrin IX detoxification pathwayBiocrystallization machinery
02
Mechanism of action
Inhibition of hemozoin formation, leading to toxic heme accumulation
03
Biological functions
Heme detoxificationHemozoin formationParasite survival
04
Disease associations
Infection (Malaria)
05
Safety considerations
Drug resistanceOff-target effects of inhibitors
06
Interacting drugs
Chloroquine
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