Target intelligence / Profile preview

Heparan Sulfate (HS)

Target: HS
Molecular classification: Glycosaminoglycan, Polysaccharide

Overview

Heparan sulfate (HS) is a linear, highly acidic polysaccharide glycosaminoglycan found in all animal tissues, primarily as part of heparan sulfate proteoglycans (HSPGs). It regulates numerous biological processes including developmental signaling, angiogenesis, blood coagulation, cell adhesion/migration, tumor metastasis, and immune cell recruitment/activation/inflammation modulation. It also acts as an attachment receptor for several viruses including respiratory syncytial virus and SARS-CoV‑2.

Other names: Heparan sulphateHSGAG

Mechanism of action

N/A

Biological functions

Developmental signalingAngiogenesisBlood coagulationCell adhesionCell migrationImmune cell recruitmentImmune cell activationInflammation modulationLigand binding

Disease associations

Tumor metastasisViral infectionsInflammation

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