Heparan sulfate 6-O-sulfotransferase 1 (HS6ST1)

Heparan sulfate 6-O-sulfotransferase 1 is an enzyme responsible for the specific transfer of sulfate to the 6-O position of glucosamine residues within heparan sulfate, a complex polysaccharide found in the extracellular matrix and on the cell surface[1][2]. This enzymatic sulfation is crucial for generating the heterogeneous structures that enable heparan sulfate to interact with numerous proteins, such as growth factors, cytokines, protease inhibitors, and viral envelope proteins, thereby playing key roles in cell signaling, development, and tissue homeostasis[2]. Mutations in HS6ST1 impair neuronal development and contribute to idiopathic hypogonadotropic hypogonadism in humans[1]. The enzyme is part of a family (HS6ST1, HS6ST2, HS6ST3) with dynamic expression during development, and its activity influences multiple signaling pathways, notably those involving fibroblast growth factors[1][2].

Other names

HS6ST1Heparan sulfate 6-O-sulfotransferase 1 (no alternative abbreviations specified in current sources)hst-6 (C. elegans ortholog)

Not specified for HS6ST1-targeting drugs. For possible future therapeutics: - Inhibition or restoration of HS6ST1 activity would be expected to alter sulfation patterns on heparan sulfate, thereby modifying downstream signaling pathways (e.g., FGF/FGFR, KAL1/anosmin-1 interactions)