Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2)

Heparan-sulfate 6-O-sulfotransferase 2 (HS6ST2) is an enzyme belonging to the heparan sulfate sulfotransferase family. It catalyzes the transfer of sulfate from 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to the 6-O position of N-sulfoglucosamine residues in heparan sulfate (HS) proteoglycans, thereby modifying the structure and biological activity of HS chains[1][5][6]. HS6ST2 plays a crucial role in cell signaling by regulating interactions between heparan sulfate proteoglycans and multiple ligands (such as growth factors), impacting processes like cell growth, differentiation, adhesion, and migration[3]. It is expressed in a tissue-specific manner, with isoforms present in the brain, eye, ovary, placenta, and fetal kidney, and is implicated in embryonic development and disease pathways. Alterations in HS6ST2 expression or function are associated with neurodevelopmental disorders, cancer progression, and fibrotic diseases. Its expression correlates with prognosis, immune cell infiltration, and drug resistance in multiple cancer types[2]. No direct drugs targeting HS6ST2 are currently listed, nor specific mechanisms of action for such drugs.

Other names

PSEC0092HS6ST-2MRXSPMheparan-sulfate 6-O-sulfotransferase 2HS6ST2