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Target intelligence / Profile preview
Heparin-binding EGF-like growth factor (HB-EGF)
- Target
- HB-EGF
- Molecular classification
- Epidermal Growth Factor family, Growth factor, Receptor ligand
01
Overview
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family. It is a multifunctional protein with significant roles in development, tissue repair, and disease processes. It acts as a potent mitogen and chemotactic agent, primarily for fibroblasts and smooth muscle cells. It binds to EGFR/ErbB1/HER1 and ErbB4/HER4 receptors and interacts with heparan sulfate proteoglycans. Membrane-bound pro-HB-EGF is also the receptor for diphtheria toxin.
- Other names
- Diphtheria toxin receptorHBEGF
02
Mechanism of action
HB-EGF binds to EGFR/ErbB1/HER1 and ErbB4/HER4 receptor tyrosine kinases, activating downstream signaling pathways. It also interacts with heparan sulfate proteoglycans.
03
Biological functions
Cell proliferationCell migrationCell differentiationWound healingCardiac developmentBlastocyst implantationSignal transductionMitogenesisChemotaxis
04
Disease associations
CancerTumor progressionMetastasisOrgan hyperplasiaVascular diseaseAtherosclerosisCardiac dysfunction
05
Safety considerations
Overexpression implicated in tumor progression and metastasis.Involvement in organ hyperplasia and vascular diseases.
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