Drug pipeline
Explore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heparin-binding EGF-like growth factor (HB-EGF)
- Target
- HB-EGF
- Molecular classification
- Epidermal Growth Factor family, Growth factor, Receptor ligand
01
Overview
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the epidermal growth factor (EGF) family. It is a multifunctional protein with significant roles in development, tissue repair, and disease processes. It acts as a potent mitogen and chemotactic agent, primarily for fibroblasts and smooth muscle cells. It binds to EGFR/ErbB1/HER1 and ErbB4/HER4 receptors and interacts with heparan sulfate proteoglycans. Membrane-bound pro-HB-EGF is also the receptor for diphtheria toxin.
- Other names
- Diphtheria toxin receptorHBEGF
02
Mechanism of action
HB-EGF binds to EGFR/ErbB1/HER1 and ErbB4/HER4 receptor tyrosine kinases, activating downstream signaling pathways. It also interacts with heparan sulfate proteoglycans.
03
Biological functions
Cell proliferationCell migrationCell differentiationWound healingCardiac developmentBlastocyst implantationSignal transductionMitogenesisChemotaxis
04
Disease associations
CancerTumor progressionMetastasisOrgan hyperplasiaVascular diseaseAtherosclerosisCardiac dysfunction
05
Safety considerations
Overexpression implicated in tumor progression and metastasis.Involvement in organ hyperplasia and vascular diseases.
Beyond the preview
Go deeper on Heparin-binding EGF-like growth factor (HB-EGF).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Follow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Compare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Investigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Explore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Connect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heparin-binding EGF-like growth factor (HB-EGF).