Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Heparin-sensitive receptor (HSR)
- Target
- HSR
- Molecular classification
- Receptor, Other
01
Overview
- Other names
- Heparin-sensitive cell-surface receptor on dendritic cells and monocytesAd5 shaft receptorKKTK-binding receptorAdenovirus fiber shaft receptor
02
Mechanism of action
The Adenovirus serotype 5 (Ad5) fiber shaft contains a KKTK motif that binds to the heparin-sensitive receptor on dendritic cells and monocytes. This binding facilitates viral entry and triggers the maturation of dendritic cells and the release of pro-inflammatory cytokines (such as IL-6 and TNF-alpha), which are necessary for the induction of potent adaptive T-cell and B-cell immune responses but also cause systemic pyrogenicity (fever).
03
Biological functions
Immune responseViral entrySignal transductionCytokine productionAntigen presentation
04
Disease associations
InfectionInflammationOther
05
Safety considerations
Pyrogenicity (fever)Systemic inflammatory response syndrome (SIRS)Dose-limiting toxicity in gene therapyPre-existing anti-Ad5 immunity affecting vector efficacy
06
Interacting drugs
Heparin
5 more in the full profile.
07
Biomarkers
Interleukin-6 (IL-6)Tumor necrosis factor-alpha (TNF-alpha)CD80CD86CD40
Beyond the preview
Go deeper on Heparin-sensitive receptor (HSR).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Heparin-sensitive receptor (HSR).