Target intelligence / Profile preview

Hepatalin

Molecular classification: Hormone, Peptide

Overview

Hepatalin is a hormone produced by the liver that plays a central role in regulating nutrient energy partitioning after meals. It stimulates glucose uptake and storage as glycogen primarily in skeletal muscle, heart, and kidneys. Reduced hepatalin action is linked to postprandial hyperglycemia, prediabetes, obesity, and type 2 diabetes.

Other names: HISSHepatic Insulin-Sensitizing Substance

Mechanism of action

Activates tissue-specific receptors to stimulate glucose uptake in muscle, heart, and kidneys.

Biological functions

Regulation of blood glucoseInsulin sensitizationGlucose uptake and storageNutrient energy partitioning

Disease associations

Type 2 diabetes mellitusPrediabetesObesityMetabolic dysfunctionAbsence of Meal-induced Insulin Sensitization (AMIS)

Safety considerations

Unknown long-term effects of synthetic hepatalin analoguesPotential for hypoglycemia if administered inappropriately

Biomarkers

AMIS (Absence of Meal-induced Insulin Sensitization)

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