Hepatic Biliary Transporters (HBTs)

Hepatic biliary transporters are membrane proteins located in hepatocytes and cholangiocytes that mediate the uptake and efflux of bile acids, bilirubin, drugs, and other compounds across the liver cell membranes. They are critical for bile formation, drug detoxification, and maintaining liver homeostasis. Dysfunction or inhibition of these transporters can lead to cholestasis and drug-induced liver injury.

Other names

Liver TransportersBile TransportersHepatic TransportersCanalicular TransportersBasolateral TransportersBile Salt Transporters

Inhibition of hepatic uptake or efflux transporters, leading to altered drug disposition and potential hepatotoxicity.