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Hepatic Glycogen Phosphorylase (None)
- Target
- None
- Molecular classification
- Enzyme, Phosphorylase, Glycoside Hydrolase
01
Overview
Hepatic glycogen phosphorylase is an enzyme found in the liver that catalyzes the rate-limiting step in glycogenolysis, the breakdown of glycogen into glucose-1-phosphate. It plays a crucial role in maintaining blood glucose homeostasis. The enzyme is encoded by the *PYGL* gene and exists as a homodimeric protein. It is regulated by phosphorylation/dephosphorylation and allosteric effectors. Mutations in *PYGL* can cause Glycogen Storage Disease Type VI (Hers Disease). Inhibitors are being explored for type 2 diabetes.
- Other names
- PYGLLiver Glycogen PhosphorylaseGlycogen phosphorylase liver isoform
02
Mechanism of action
Inhibition of glycogenolysis
03
Biological functions
GlycogenolysisBlood glucose regulationGlucose homeostasis
04
Disease associations
Glycogen Storage Disease Type VI (Hers Disease)Type 2 DiabetesHyperglycemia
05
Safety considerations
Potential for hypoglycemia if over-inhibitedHepatomegaly
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